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2009-08

Adaptive Designs for Dose Escalation Studies

by Roth, K..


Series: 2009-08, Preprints

MSC:
62K05 Optimal designs
62L05 Sequential design
62P10 Applications to biology and medical sciences

Abstract:
In Phase I dose escalation studies the 3+3 design is a commonly used method. We suggest a modification of this method to include a parametric model and the concepts of optimal design theory, with the aim of improving this method. The performance of the original and the new approach are
investigated by simulations.

Keywords:
optimal design, adaptive design, dose escalation studies