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Sequential Designs for Dose Escalation Studies

by Roth, K..

Series: 2010-18, Preprints

62K05 Optimal designs
62L05 Sequential design
62P10 Applications to biology and medical sciences

In Phase I dose escalation studies the 3+3 design is a commonly used method. We suggest a modification of this method to include a parametric model and the concepts of optimal design theory, with the aim of improving this method. The performance of the original and the new approach are investigated by simulations.

optimal design, adaptive design, dose escalation studies